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Hematopoiesis in an adult

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959 08.08.2019
Lab Eirini Trompouki. Being multipotent and capable of self-renewal, HSCs are responsible for constant production of all blood cell types throughout life. Because of their properties, HSCs are highly demanded in clinic daily. For example, HSCs are used for replenishing the hematopoietic system of acute myeloid leukemia AML patients after chemotherapy or for patients that need blood transfusions. However, due to their limited number and our inability to expand them sufficiently in vitro it is impossible, right now, to provide for these extensive needs. In addition, alterations in the properties of HSCs and their environment lead to disease.
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Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells

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Hematopoiesis: Definition, where it occurs, process, and types

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Adult haematopoietic stem cell niches

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The yolk sac is the first observed site of hematopoiesis during mouse ontogeny. Primitive erythroid cells are the most well-recognized cell lineages produced from this tissue. In addition to primitive erythroid cells, several types of hematopoietic cells are present, including multipotent hematopoietic progenitors.

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